http://mars.jpl.nasa.gov/msl/multimedia/raw/?rawid=0195MH0231000000E1_DXXX&s=195
Based on the information in the description above at the linked image page, you could measure the small hole, in micrometers. You would be required to have the figure for a MAHLI turret position to obtain the measure.
The image below gives a view of nearby rocks bearing a large distributed portion of small spheroids.
The small pebbles on the rover were about 1-3 millimeters, some larger, some smaller. They were irregular in shape.
Why would the occasional hole be present in layered material? Why a round shape to the hole? Why a single hole?Are you considering answers for this?
Would a single spheroid be a sufficient reason for the hole like your topic image shows?
Do you believe the layering is caused by chemistry or deposition in this area?